pISSN 3022-6783
eISSN 3022-7712

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Korean J Transplant 2021; 35(4): 208-217

Published online December 31, 2021

https://doi.org/10.4285/kjt.21.0033

© The Korean Society for Transplantation

Mycobacterial infections in solid organ transplant recipients

Harun Ur Rashid , Nura Afza Salma Begum , Tasnuva Sarah Kashem

Department of Nephrology, Kidney Foundation Hospital and Research Institute, Dhaka, Bangladesh

Correspondence to: Harun Ur Rashid
Department of Nephrology, Kidney Foundation Hospital and Research Institute, Plot no. 5/2, Road no. l, section 2, Mirpur, Dhaka 1216, Bangladesh
Tel: +880-18-1924-7299
E-mail: rashid@bol-online.com

Received: December 22, 2021; Accepted: December 25, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mycobacterium tuberculosis (MTB) infection in solid organ transplant (SOT) recipients remains a major challenge for physicians and surgeons. Active tuberculosis (TB) is associated with increased morbidity and mortality in SOT recipients. MTB usually develops after transplantation in a recipient with latent TB infection (LTBI) before transplantation and may also be transmitted from the donor or acquired from the community. Therefore, screening for LTBI in donors and recipients before transplantation is very important in preventing active disease after transplantation. This review article is based on recently published data, case series, and expert recommendations. We reviewed updated information about the epidemiology, diagnosis, and treatment of latent and active TB before and after transplantation. We also reviewed recent treatments for multidrug-resistant TB.

Keywords: Mycobacterium tuberculosis, Latent tuberculosis infection, Solid organ transplantation, Multidrug-resistant tuberculosis

HIGHLIGHTS
  • Active tuberculosis (TB) is associated with increased morbidity and mortality in solid organ transplant recipients.

  • Screening for latent TB infection in donor and recipient before transplant is very important in preventing active disease after transplantation.

  • Management of TB is becoming difficult due to the emergence of multidrug-resistant cases.