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Korean J Transplant 2020; 34(3): 154-166

Published online September 30, 2020

https://doi.org/10.4285/kjt.2020.34.3.154

© The Korean Society for Transplantation

Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study

Hyoung Won Koh1 , Kyunglim Koo1 , Chang Sik Shin1 , Hyung Sub Park1,2 , Jong Cheol Jeong3 , Sejoong Kim3 , Dong Wan Chae3 , Jong Jin Oh4 , Seok-Soo Byun4 , Taeseung Lee1,2

1Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea
2Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
3Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
4Department of Urology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea

Correspondence to: Taeseung Lee
Department of Surgery, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea
Tel: +82-31-787-7999
Fax: +82-31-787-4055
E-mail: tslee@snubh.org

Received: June 26, 2020; Revised: August 16, 2020; Accepted: August 17, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Kidney transplantation (KT) is regarded as the most effective treatment for end-stage renal disease. The annual number of KT cases in South Korea has increased rapidly as more centers are implementing a transplantation program. The objective of this study was to determine clinical outcomes of the first 300 consecutive cases of KT in a single center.

Methods: Clinical data of 300 cases of KT at Seoul National University Bundang Hospital from January 2004 to March 2018 were obtained from a prospectively collected database and retrospectively reviewed.

Results: The mean age of patients was 47.7±12.9 years, and 59% of patients were male. There were 225 living donors and 75 deceased donors. A total of 42 cases were from ABO-incompatible donors. During a mean follow-up of 68.6±43.5 months, 38 patients (12.7%) experienced rejection. The most common cause was acute T-cell mediated rejection (9.0%). Eighteen patients experienced graft loss. One-year and 5-year death-censored graft survival rates were 99% and 96.6%, respectively. One-year and 5-year patient survival rates were 98.3% and 96.6%, respectively. Multivariate analysis revealed that graft weight-to-recipient weight ratio and rejection were significant factors affecting graft survival.

Conclusions: This single-center review demonstrates clinical outcomes comparable to other major centers. Such good outcomes were obtained by good patient selection, dedicated transplant physicians, and adequate use of immunosuppressive therapy.

Keywords: Transplantation, Kidney transplantation

HIGHLIGHTS
  • This study reports clinical outcomes of the first 300 consecutive cases of kidney transplantation at a single low-volume center.

  • Our center has performed 300 cases of kidney transplantation over a period of 14 years since its first case in 2005 and is now performing >50 cases per year.

  • One-year and 5-year death-censored graft survival rates were 99% and 96.6%, respectively.

  • One-year and 5-year patient survival rates were 98.3% and 96.6%, respectively.

  • Clinical outcomes up to date are comparable to prior reports from other leading centers.