pISSN 3022-6783
eISSN 3022-7712

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J Korean Soc Transplant 2011; 25(4): 229-238

Published online December 31, 2011

https://doi.org/10.4285/jkstn.2011.25.4.229

© The Korean Society for Transplantation

Cardiovascular Diseases after Solid Organ Transplantation

Jae-Joong Kim, Ph.D.

Department of Internal Medicine, Asan Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Correspondence to: 김재중, 서울시 송파구 올림픽로 43길 88 울산대학교 의과대학 서울아산병원 내과, 138-736
Tel: 02-3010-3154, Fax: 02-486-5918
E-mail: jjkim@amc.seoul.kr

Received: November 30, 2011; Accepted: November 30, 2011

Abstract

Despite recent advances in the prolongation of patient and graft survival, transplant patients continue to die prematurely of cardiovascular disease. Cardiovascular disease after solid organ transplantation is a serious complication caused by numerous factors, most shared with the general population and others specific to transplant recipients including immunosuppressive drugs and renal dysfunction. Among traditional risk factors in general population, hypertension, dyslipidemia and diabetes are more common in solid organ transplant recipients. The control of risk factors is more difficult in transplant recipients than in general population. Immunosuppressive drugs are related to hypertension, dyslipidemia and posttransplant DM. Reduction of immunosuppression is helpful to reduce the risk of cardiovascular disease but may increase the risk of rejection and graft loss. mTOR inhibitor has less potential risk to develop cardiovascular disease. Future development of new immunosuppressive drug with less potential risk of CV disease but same efficacy to prevent rejection and graft loss will be a promising goal to prevent CV disease. In conclusion, multidisciplinary approach that emphasizes evidence-based management of traditional risk factors and development of new immunosuppressive drugs are the best approach to reducing the risk of CV disease after solid organ transplantation.

Keywords: Solid organ transplantation, Cardiovascular diseases, Risk factors