pISSN 3022-6783
eISSN 3022-7712


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J Korean Soc Transplant 2011; 25(1): 8-14

Published online March 31, 2011


© The Korean Society for Transplantation

Management of Posttransplantation Diabetes Mellitus (PTDM)

Bong Soo Cha, M.D. and Jae Hoon Moon, M.D.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Correspondence to: 차봉수, 서울시 서대문구 성산로 250 연세대학교 의과대학 내과학교실 내분비내과, 120-752
Tel: 02-2228-1962, Fax: 02-393-6884
E-mail: bscha@yuhs.ac

Received: February 28, 2011; Accepted: March 3, 2011


New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation. As long-term posttransplant survival continues to improve, increasing attention has been placed on NODAT. Because NODAT is a potent predictor of graft failure and cardiovascular mortality in the transplant population, early detection and management of NODAT are important issues. The risk factors for NODAT in transplant recipients include older age, obesity, family history, hepatitis C virus infection, and immunosuppressive agents, such as corticosteroids and calcineurin inhibitors. Management of NODAT must be considered at the pretransplantation stage to screen high risk patients and prevent NODAT. Although NODAT management is similar to type 2 diabetes management in the general population, there are some specific considerations in NODAT management, including the immunosuppressive agent. Further studies are needed to suggest optimal management guidelines for NODAT.

Keywords: Diabetes mellitus, Organ transplantation, Risk factors, Postoperative complications, Diagnosis, Treatment outcome