This study was conducted to identify factors affecting psychosocial adjustment in liver donors after living liver donation. The study was comprised of 121 liver donors who underwent liver donation surgery. The survey data was collected from August 10 to November 10, 2021. The questionnaire consisted of general characteristics, donation-related characteristics, knowledge, uncertainty, and psychosocial adjustment tools. It was analyzed by descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation coefficient, and multiple regression analysis using SPSS ver. 25.0 program. The result of the study showed the lower the uncertainty of the liver donor (β=–0.698, P<0.001), the higher the economic level (β=0.180, P<0.01), and the higher recommendation of the liver donation (β=0.120, P<0.05), the higher level of psychosocial adjustment (F=65.479, P<0.001). Therefore, in order to increase the level of psychosocial adjustment of liver donors, it is necessary to develop nursing intervention and education programs, reduce the uncertainty of liver donors, and provide medical cost support system and cost-related counselling. This would have a positive impact on donation recommendations and help the increase in number of living liver donors.