Background: Kidney transplantation (KT) is the optimal treatment for patients with end-stage renal disease (ESRD). Living donor (LD) KT had the superior results for the recipient, but in recent years, the number of patients for deceased donor (DD) KT is increasing worldwide. This study was carried out to determine survival outcomes between the recipients in LDKT and DDKT.
Methods: Data were collected retrospectively for 128 KT recipients including 101 LDKT and 27 DDKT recipients, performed from 2016 to 2021 in the organ transplant center of First Central Hospital of Mongolia. Demographics, delayed graft function (DGF), 1- and 5-year patient and KT survival for the LD group were compared to the DD group using one way analysis of variance and Kaplan-Meier tests. DGF was defined as the need for at least one dialysis session in the first week after KT.
Results: Mean age of the recipients was 37.4±10.4 years and male gender was dominant among them. Mean age of the donors was 42.8±10.1 years and donor gender ratio was 1:1. The main primary disease for ESRD was glomerulonephritis (87.5%). Mean hemoglobin of the recipients was 10.5±1.5 g/dL, albumin 39.7±5.3 g/L, total protein 64.4±9.8 g/L, and serum C reactive protein 8.2±11.9 mg/dL. The incidence of DGF in LD and DD group were 3 (2.9 %) and 8 (29.6 %), respectively (P<0.001). Human leukocyte antigen mismatches (4–6) in LD and DD group were 19 (27.9%) and 10 (55.6%), respectively (P<0.05). One- and 5-year overall KT survival were 94% and 81%, and overall patient survival were 98% and 88%, respectively. KT 1- and 5-year survival for LDKT were 95% and 81%, for DDKT were 88% and 72%, respectively (P=0.148). One- and 5-year patient survival for LDKT were 100% and 87%, for DDKT were 88% and 88%, respectively (P=0.136).
Conclusions: We need to further study influencing factors on kidney transplant outcome and its relationship.