The roles of Th17 and IL-17 in allograft rejection
Study | Type of allograft | Subject | Findings |
---|---|---|---|
Wang et al. (2022) [23] | Kidney | Rats | • IL-17 levels increased in kidney grafts |
Chung et al. (2015) [24] | Kidney | Humans | • Th17 cell and IL-17 levels increased in peripheral blood and serum, respectively • IL-17 increased the expression of profibrotic genes, including |
Crispim et al. (2009) [25] | Kidney | Humans | • IL-17 levels increased in serum |
Haouami et al. (2018) [26] | Kidney | Humans | • IL-17 and IL-23 levels increased in plasma |
Deteix et al. (2010) [54] | Kidney | Humans | • Th17 cell levels increased in kidney grafts |
Negi et al. (2024) [40] | Kidney | Humans | • Allogeneic stimulation of PBMCs from highly sensitized patients with donor APCs showed higher percentages of CD4+ T cells expressing IL-17A than nonsensitized patients |
Xie et al. (2010) [28] | Liver | Rats | • Th17 cell levels increased in the liver and peripheral blood • IL-17 levels in liver homogenate and serum increased |
Assadiasl et al. (2022) [29] | Liver | Humans | • Th17 cell levels increased in peripheral blood • Th17 cell frequency was negatively associated with liver allograft functions |
Fan et al. (2012) [30] | Liver | Humans | • Th17 cell levels increased in peripheral blood. • Th17 cell frequency was negatively correlated with the rejection activity index |
Afshari et al. (2014) [31] | Liver | Humans | • IL-17 levels increased in serum |
Fábrega et al. (2009) [32] | Liver | Humans | • IL-17 and IL-23 levels increased in serum |
Wang et al. (2019) [55] | Liver | Humans | • Th17 cell levels increased in peripheral blood |
Antonysamy et al. (1999) [15] | Heart | Mice | • Prolonged nonvascularized or vascularized cardiac allograft survival and inhibition of T cell proliferation were observed after treatment of recombinant mIL-17R: Fc fusion protein to inhibit IL-17 action • Phenotypic differentiation of DC progenitors after treatment of recombinant IL-17 to bone marrow-derived cells |
Min et al. (2009) [33] | Heart | Mice | • Th17 cell frequencies increased among splenocytes • IL-17 levels increased in serum |
Wang et al. (2011) [34] | Heart | Humans | • Th17 cell levels increased in peripheral blood |
Itoh et al. (2010) [41] | Heart | Mice | • Weaker chronic rejection was observed after transplant to IL-17 deficient recipient mice • γ: δ T cells was as a main source of IL-17 after transplant to wild-type recipient mice |
Zhang et al. (2021) [43] | Heart | Mice | • Weaker acute rejection, and decrease in Th17 cell infiltration and IL-17 expression in myocardial tissue were observed after treatment of JAK2/STAT3 signaling inhibitor AG490 |
Yuan et al. (2008) [44] | Heart | Mice | • Infiltration of Th17 cells into allografts was promoted after transplant to T-bet-deficient recipient mice • Neutralization of IL-17 with anti-IL17 weakened allograft rejection |
Chen et al. (2016) [38] | Lungs | Mice | • Increase in IL-17 levels in lung graft • Weaker acute rejection was observed after neutralization of IL-17A with anti-IL-17A |
Vanaudenaerde et al. (2006) [39] | Lungs | Humans | • Increase in IL-17 levels in bronchoalveolar lavage |
Watanabe et al. (2023) [42] | Lungs | Mice | • Weaker acute rejection was observed after transplant to donor mice deficient in IL-17A receptor and administration of LPS |
Chen et al. (2009) [35] | Cornea | Mice | • Increase in Th17 cell levels in cervical draining lymph nodes |
Yang et al. (2013) [36] | Intestine | Rats | • Increase in Th17 cell levels in intestine grafts |
Zheng et al. (2014) [37] | Skin | Rats | • Increase in Th17 cell percentages among splenocytes • Increase in IL-17 in serum |
Agorogiannis et al. (2012) [9] | Skin | Mice | • Infusion of recipient mice with Marilyn-derived “long-term” Th17 cells caused dense infiltration of neutrophils in skin grafts |
Th17, T helper 17; IL, interleukin; PBMC, peripheral blood mononuclear cell; APC, antigen-presenting cell; DC, dendritic cell; JAK2/STAT3, Janus kinase 2/signal transducer and activator of transcription 3; LPS, lipopolysaccharide.