Fig. 1. SARS-CoV-2 vaccine-induced T cell responses in SOTRs. T cell response to SARS-CoV-2 vaccines is significantly weaker in SOTRs than in healthy controls. Additional booster vaccinations have increased the frequency of virus-specific T cells, CD45RA+ effector memory (TEMRA) subpopulations, and cytokine-producing capacity, although SOTRs exhibit lesser T cell responses compared to healthy controls. Boosting vaccinations might contribute to lower breakthrough infection rates and reduced disease severity of coronavirus disease 2019 (COVID-19). SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SOTRs, solid organ transplant recipients.
Clin Transplant Res 2024;38:247~256 https://doi.org/10.4285/ctr.24.0062