Fig. 2. Effects of immunosuppressive regimens on Treg dynamics post-LT. This figure illustrates the impact of various immunosuppressive agents on Tregs following LT. Glucocorticoids initially increase Treg levels at low doses but decrease them at high doses. High doses of tacrolimus reduce Tregs, whereas mycophenolate mofetil has a neutral effect on Tregs. Basiliximab, administered on days 0 and 4, has a transient Treg depletion effect. Everolimus, which may be introduced around day 30, increases Treg levels. Early reduction of Tregs by day 7 is associated with a higher risk of graft rejection, as indicated by flow cytometry data for FOXP3+CD25+ Tregs. Treg, regulatory T cell; IV, intravenous; PO, oral; LT, liver transplantation.