Fig. 2. Characteristics of LLPCs. LLPCs exhibit numerous characteristics that distinguish them from SLPCs. Molecules associated with plasma cell survival and function are upregulated in LLPCs, whereas B cell markers are downregulated. These molecular changes not only contribute to the resistance of LLPCs to traditional cytostatic treatments and B cell depletion therapies but also inform the mechanisms of action for ongoing therapeutic trials. SLPC, short-lived plasma cell; LLPC, long-lived plasma cell; ATG, autophagy gene; BCMA, B cell maturation antigen.
Clin Transplant Res 2024;38:341~353 https://doi.org/10.4285/ctr.24.0047