Fig. 3. Regulation of germinal center activation and B cell maturation by interleukin 6. APC, antigen-presenting cell; HLA, human leukocyte antigen; IL, interleukin; IgG, immunoglobulin G; TCR, T cell receptor; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; ADCC, antibody dependent cellular cytotoxicity; FCGR, Fc gamma receptor; NK, natural killer; IFN, interferon; TNF, tumor necrosis factor; BAFF, B cell activating factor; APRIL, a proliferation-inducing ligand; Tregs, regulatory T cell; Bregs, regulatory B cell; IgD, immunoglobulin D; AMR, antibody-mediated rejection. Adapted from Jordan et al. [
13] with permission from Elsevier.
