Fig. 2. Receiver operating characteristic (ROC) curve analysis of insulin-like growth factor-binding protein 7 (IGFBP7), tissue inhibitor of metalloprotease-2 (TIMP-2), and [TIMP-2]×[IGFBP7] as markers of acute graft dysfunction. (A) IGFBP7 was able to diagnose acute allograft dysfunction with a sensitivity of 97.0%, specificity of 93.3%, and area under the curve (AUC) of 0.97 at a cutoff level of 0.65 pg/mg creatinine. (B) TIMP-2 was able to diagnose acute allograft dysfunction with a sensitivity of 69.7%, specificity of 100%, and AUC 0.91 at cutoff level 519.3 ng/mg creatinine. (C) The [TIMP-2]×[IGFBP7] at its cutoff level 0.278 (ng/mL)2/1,000 had a sensitivity of 100%, specificity of 93.3%, and AUC 0.99 in diagnosing acute graft dysfunction. (D) ROC curves analysis of IGFBP7, TIMP-2, and the [TIMP-2]×[IGFBP7] as markers of acute rejection. IGFBP7 was able to diagnose acute rejection with a sensitivity of 77.8%, specificity of 86.7%, and AUC 0.881 at a cutoff level of 1.3 pg/mg creatinine. (E) TIMP-2 was able to diagnose acute rejection with a sensitivity of 94.4%, specificity of 56.7%, and AUC 0.800 at a cutoff level of 439.1 ng/mg creatinine. (F) The [TIMP-2]×[IGFBP7] at its cutoff level 0.803 (ng/mL)2/1,000 had a sensitivity of 94.4%, specificity of 83.3%, and AUC 0.939 in diagnosing acute rejection. Red stars correspond to optimum criterion cut-off points.
